The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure.Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex chicago skyline graffiti determination and
The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained for a series of pteridinone-,
Across bacteria, protein-based organelles called bacterial microcompartments (BMCs) encapsulate key enzymes to regulate their activities.The model BMC is the carboxysome that encapsulates enzymes for CO2 fixation to increase efficiency and is found in many autotrophic bacteria, such as cyanobacteria.Despite their importance in the global carbon cyc
BackgroundDevelopmental Dysplasia of the Hip (DDH) is a relatively common hip joint disorders in infants, affecting one to three per a thousand births.If found early, it can be treated preemptively by simple non-invasive methods.But if not, then several surgical procedures may be required that can cause high economic burden.The accuracy of diagnosi